Hello our fellow CBD enthusiasts! Today it’s time to get familiar with Caryophyllene.
Caryophyllene – is a common and often abundant terpene found in cannabis. Its distinctive flavor contributes to the spiciness of black pepper and can be found in high amounts in cloves, hops, and rosemary. It falls under the FDA’s “generally recognized as safe” classification, so large doses can be safely consumed.
Pain – The data suggest that, in many cases, caryophyllene can provide pain relief. In one study, scientists injected mice with caryophyllene and found that they experienced less pain than those treated with the control solution. Furthermore, caryophyllene enhanced the pain-reducing strength of low-dose morphine. This could be one reason why those using prescription opioids from pain are often able to decrease their dose of opioids when they begin using medical cannabis.
Sleep – In combination with other terpenes, caryophyllene has shown promise as a sedative. A 2012 study published in the journal Pharmaceutical Biology found that mice treated with essential oil containing caryophyllene experienced increased sleep time as well as decreased locomotion and body temperature.
Pain – A 2013 study published in the European Journal of Pain found that when mice exposed to capsaicin were injected with caryophyllene, they experienced pain relief. The terpene was also found to enhance the pain-relieving properties of low doses of morphine.
Diabetes – When it comes to other potential beta-caryophyllene benefits, there is evidence indicating that the terpene, along with standard diabetic medicine, helps balance glucose levels in rats with diabetes, according to a 2014 study published in the journal Acta Histochemica.
Inflammation and brain aging – There are numerous inflammatory diseases that affect the digestive tract. Colitis is one such disease where inflammation of the intestines causes pain, diarrhea, abdominal cramping, and even increases risk for cancer. In mice that were experimentally given colitis, treatment with caryophyllene helped by decreasing inflammation in the colon.
The activation of CB2 receptors by caryophyllene certainly plays a role in its anti-pain effects, but it also contributes to its ability to protect the body and brain from disease. For instance, brain inflammation plays a substantial role in the onset and progression of Alzheimer’s disease. In a mouse model of Alzheimer’s disease, caryophyllene activated CB2 and PPAR-γ receptors and reduced hallmark features of Alzheimer’s such as the accumulation of brain plaques. These actions also protect against the cognitive decline that characterizes this model of disease.